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To evaluate whether a watershed is stressed, we considered the common use-to-availability thresholds of 20 percent and 40 percent to define moderate and severe water scarcity

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Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]

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